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TLK1 has not been detected as a mutational cancer driver

TLK1
Ensembl id ENSG00000198586
Mutated samples
Coding Sequence 38 (0.6%)
Protein Affecting 28 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TLK1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 7 6 1.53
Cutaneous melanoma No 5 4 1.08
Head and neck squamous cell carcinoma No 4 3 0.80
Prostate adenocarcinoma No 3 2 0.82
Lung squamous cell carcinoma No 3 2 1.15
Uterine corpus endometrioid carcinoma No 2 2 0.87
Stomach adenocarcinoma No 2 2 1.24
Hepatocarcinoma No 2 1 1.11
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
Breast carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence