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THRAP3 mutations in 7 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Prostate adenocarcinoma, Bladder carcinoma, Acute myeloid leukemia, Breast carcinoma, Lung squamous cell carcinoma, Stomach adenocarcinoma, Head and neck squamous cell carcinoma

THRAP3
Ensembl id ENSG00000054118
Mutated samples
Coding Sequence 60 (0.9%)
Protein Affecting 51 (0.8%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all THRAP3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 4 4 2.48
Breast carcinoma Yes 3 3 0.26
Head and neck squamous cell carcinoma Yes 3 3 0.80
Prostate adenocarcinoma Yes 3 2 0.82
Bladder carcinoma Yes 2 2 2.04
Acute myeloid leukemia Yes 2 2 1.02
Lung squamous cell carcinoma Yes 2 2 1.15
Cutaneous melanoma No 11 10 2.71
Uterine corpus endometrioid carcinoma No 9 8 3.48
Lung adenocarcinoma No 6 6 1.53
Renal clear cell carcinoma No 4 4 0.96
Serous ovarian adenocarcinoma No 5 4 1.27
Diffuse B cell lymphoma No 1 1 4.35
Hepatocarcinoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence