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TDRD5 has not been detected as a mutational cancer driver

TDRD5
Ensembl id ENSG00000162782
Mutated samples
Coding Sequence 138 (2.0%)
Protein Affecting 96 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TDRD5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 65 47 12.74
Lung squamous cell carcinoma No 14 12 6.90
Lung adenocarcinoma No 15 11 2.81
Head and neck squamous cell carcinoma No 8 6 1.60
Renal clear cell carcinoma No 3 3 0.72
Breast carcinoma No 5 2 0.17
Neuroblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 3 2 0.87
Chronic lymphocytic leukemia No 5 2 0.69
Glioblastoma multiforme No 2 2 0.53
Bladder carcinoma No 2 1 1.02
Serous ovarian adenocarcinoma No 2 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Non small cell lung carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence