Top
STAT1 has not been detected as a mutational cancer driver

STAT1
Ensembl id ENSG00000115415
Mutated samples
Coding Sequence 64 (0.9%)
Protein Affecting 44 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all STAT1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma No 6 6 2.61
Head and neck squamous cell carcinoma No 9 6 1.60
Cutaneous melanoma No 10 5 1.36
Lung adenocarcinoma No 7 4 1.02
Bladder carcinoma No 4 4 4.08
Renal clear cell carcinoma No 4 4 0.96
Lung squamous cell carcinoma No 4 2 1.15
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 2 2 1.24
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Breast carcinoma No 2 1 0.09
Thyroid carcinoma No 1 1 0.31
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Esophageal carcinoma No 2 1 0.68
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence