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SPEG has not been detected as a mutational cancer driver

SPEG
Ensembl id ENSG00000072195
Mutated samples
Coding Sequence 224 (3.3%)
Protein Affecting 143 (2.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SPEG gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 63 41 11.11
Lung adenocarcinoma No 30 22 5.63
Lung squamous cell carcinoma No 14 10 5.75
Stomach adenocarcinoma No 18 10 6.21
Breast carcinoma No 13 9 0.78
Uterine corpus endometrioid carcinoma No 14 6 2.61
Head and neck squamous cell carcinoma No 13 6 1.60
Glioblastoma multiforme No 8 6 1.58
Esophageal carcinoma No 8 6 4.11
Bladder carcinoma No 10 5 5.10
Renal clear cell carcinoma No 5 5 1.20
Prostate adenocarcinoma No 6 3 1.23
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 3 2 0.63
Colorectal adenocarcinoma No 3 2 0.87
Acute lymphocytic leukemia No 2 2 1.64
Hepatocarcinoma No 2 1 1.11
Acute myeloid leukemia No 2 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Chronic lymphocytic leukemia No 2 1 0.34
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Non small cell lung carcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence