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SMG7 has not been detected as a mutational cancer driver

SMG7
Ensembl id ENSG00000116698
Mutated samples
Coding Sequence 133 (2.0%)
Protein Affecting 59 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SMG7 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 32 15 4.07
Lung squamous cell carcinoma No 14 8 4.60
Uterine corpus endometrioid carcinoma No 11 8 3.48
Colorectal adenocarcinoma No 5 4 1.75
Prostate adenocarcinoma No 6 3 1.23
Breast carcinoma No 11 3 0.26
Stomach adenocarcinoma No 5 3 1.86
Esophageal carcinoma No 5 3 2.05
Lung adenocarcinoma No 6 2 0.51
Bladder carcinoma No 5 2 2.04
Head and neck squamous cell carcinoma No 10 2 0.53
Glioblastoma multiforme No 7 2 0.53
Renal clear cell carcinoma No 2 1 0.24
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 2 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Lower grade glioma No 1 0 0.00
Serous ovarian adenocarcinoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence