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SLIT2 has not been detected as a mutational cancer driver

SLIT2
Ensembl id ENSG00000145147
Mutated samples
Coding Sequence 247 (3.6%)
Protein Affecting 173 (2.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SLIT2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 86 66 17.89
Lung adenocarcinoma No 24 19 4.86
Lung squamous cell carcinoma No 16 13 7.47
Head and neck squamous cell carcinoma No 15 13 3.47
Stomach adenocarcinoma No 17 11 6.83
Breast carcinoma No 10 9 0.78
Small cell lung carcinoma No 7 7 10.14
Esophageal carcinoma No 11 6 4.11
Colorectal adenocarcinoma No 5 5 2.18
Pancreas adenocarcinoma No 3 3 1.40
Renal clear cell carcinoma No 7 3 0.72
Uterine corpus endometrioid carcinoma No 4 3 1.30
Chronic lymphocytic leukemia No 13 3 1.03
Glioblastoma multiforme No 7 3 0.79
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 4 2 1.18
Serous ovarian adenocarcinoma No 3 2 0.63
Neuroblastoma No 2 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 2 1 1.45
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Bladder carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence