Top
SLC8A1 has not been detected as a mutational cancer driver

SLC8A1
Ensembl id ENSG00000183023
Mutated samples
Coding Sequence 185 (2.7%)
Protein Affecting 117 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SLC8A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 53 34 9.21
Lung adenocarcinoma No 31 22 5.63
Lung squamous cell carcinoma No 18 13 7.47
Head and neck squamous cell carcinoma No 10 8 2.13
Esophageal carcinoma No 8 7 4.79
Breast carcinoma No 4 4 0.35
Stomach adenocarcinoma No 10 4 2.48
Bladder carcinoma No 3 3 3.06
Colorectal adenocarcinoma No 3 3 1.31
Hepatocarcinoma No 6 2 2.22
Thyroid carcinoma No 2 2 0.62
Uterine corpus endometrioid carcinoma No 3 2 0.87
Multiple myeloma No 2 2 2.90
Serous ovarian adenocarcinoma No 2 2 0.63
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Pancreas adenocarcinoma No 2 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 12 1 0.34
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Pylocytic astrocytoma No 5 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence