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SH3KBP1 has not been detected as a mutational cancer driver

SH3KBP1
Ensembl id ENSG00000147010
Mutated samples
Coding Sequence 58 (0.9%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SH3KBP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 16 13 3.52
Breast carcinoma No 8 6 0.52
Head and neck squamous cell carcinoma No 6 5 1.33
Lung squamous cell carcinoma No 3 3 1.72
Renal clear cell carcinoma No 3 3 0.72
Lung adenocarcinoma No 3 2 0.51
Uterine corpus endometrioid carcinoma No 4 2 0.87
Stomach adenocarcinoma No 3 2 1.24
Hepatocarcinoma No 1 1 1.11
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 2 1 0.44
Bladder carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence