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SEC31A is detected as a mutational cancer driver in 1 cancer type: Uterine corpus endometrioid carcinoma

SEC31A
Ensembl id ENSG00000138674
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 47 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
UCEC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SEC31A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 6 6 2.61
Breast carcinoma No 9 8 0.70
Lung adenocarcinoma No 7 6 1.53
Cutaneous melanoma No 12 6 1.63
Head and neck squamous cell carcinoma No 7 5 1.33
Bladder carcinoma No 5 3 3.06
Lung squamous cell carcinoma No 3 3 1.72
Renal clear cell carcinoma No 4 2 0.48
Stomach adenocarcinoma No 4 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Medulloblastoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Multiple myeloma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence