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SCN5A has not been detected as a mutational cancer driver

SCN5A
Ensembl id ENSG00000183873
Mutated samples
Coding Sequence 230 (3.4%)
Protein Affecting 175 (2.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SCN5A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 100 80 21.68
Breast carcinoma No 15 13 1.13
Lung adenocarcinoma No 18 10 2.56
Stomach adenocarcinoma No 12 10 6.21
Lung squamous cell carcinoma No 10 9 5.17
Uterine corpus endometrioid carcinoma No 13 7 3.04
Prostate adenocarcinoma No 8 6 2.47
Glioblastoma multiforme No 9 6 1.58
Esophageal carcinoma No 6 6 4.11
Colorectal adenocarcinoma No 6 5 2.18
Head and neck squamous cell carcinoma No 7 5 1.33
Pancreas adenocarcinoma No 3 3 1.40
Hepatocarcinoma No 2 2 2.22
Bladder carcinoma No 2 2 2.04
Thyroid carcinoma No 3 2 0.62
Serous ovarian adenocarcinoma No 4 2 0.63
Renal clear cell carcinoma No 2 1 0.24
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 3 1 0.34
Multiple myeloma No 2 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence