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RTN4 mutations in 8 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Hepatocarcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Stomach adenocarcinoma, Colorectal adenocarcinoma, Esophageal carcinoma

RTN4
Ensembl id ENSG00000115310
Mutated samples
Coding Sequence 53 (0.8%)
Protein Affecting 45 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RTN4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 11 10 2.71
Colorectal adenocarcinoma Yes 3 3 1.31
Lung adenocarcinoma Yes 2 2 0.51
Hepatocarcinoma Yes 4 2 2.22
Lung squamous cell carcinoma Yes 3 2 1.15
Uterine corpus endometrioid carcinoma Yes 2 2 0.87
Stomach adenocarcinoma Yes 2 2 1.24
Esophageal carcinoma Yes 3 2 1.37
Breast carcinoma No 9 9 0.78
Head and neck squamous cell carcinoma No 5 5 1.33
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 2 1 0.24
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence