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RIF1 has not been detected as a mutational cancer driver

RIF1
Ensembl id ENSG00000080345
Mutated samples
Coding Sequence 160 (2.4%)
Protein Affecting 104 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RIF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 17 4.61
Lung adenocarcinoma No 12 12 3.07
Breast carcinoma No 15 12 1.05
Small cell lung carcinoma No 9 8 11.59
Head and neck squamous cell carcinoma No 11 8 2.13
Stomach adenocarcinoma No 9 7 4.35
Lung squamous cell carcinoma No 7 6 3.45
Renal clear cell carcinoma No 10 5 1.20
Uterine corpus endometrioid carcinoma No 13 5 2.17
Serous ovarian adenocarcinoma No 8 5 1.58
Bladder carcinoma No 6 4 4.08
Lower grade glioma No 5 3 1.78
Colorectal adenocarcinoma No 6 3 1.31
Prostate adenocarcinoma No 2 2 0.82
Chronic lymphocytic leukemia No 2 2 0.69
Esophageal carcinoma No 3 2 1.37
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 2 1 0.47
Multiple myeloma No 1 1 1.45
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Glioblastoma multiforme No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence