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RGS12 has not been detected as a mutational cancer driver

RGS12
Ensembl id ENSG00000159788
Mutated samples
Coding Sequence 95 (1.4%)
Protein Affecting 51 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RGS12 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 24 14 3.79
Lung squamous cell carcinoma No 8 7 4.02
Breast carcinoma No 7 5 0.44
Lung adenocarcinoma No 9 4 1.02
Bladder carcinoma No 5 3 3.06
Stomach adenocarcinoma No 5 3 1.86
Head and neck squamous cell carcinoma No 10 3 0.80
Glioblastoma multiforme No 3 3 0.79
Renal clear cell carcinoma No 3 2 0.48
Thyroid carcinoma No 5 2 0.62
Prostate adenocarcinoma No 3 1 0.41
Neuroblastoma No 2 1 0.48
Uterine corpus endometrioid carcinoma No 2 1 0.43
Serous ovarian adenocarcinoma No 1 1 0.32
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 2 0 0.00
Small cell lung carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence