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RFC1 has not been detected as a mutational cancer driver

RFC1
Ensembl id ENSG00000035928
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 36 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RFC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 10 7 1.90
Breast carcinoma No 7 4 0.35
Lung adenocarcinoma No 4 3 0.77
Renal clear cell carcinoma No 5 3 0.72
Uterine corpus endometrioid carcinoma No 6 3 1.30
Head and neck squamous cell carcinoma No 4 3 0.80
Bladder carcinoma No 2 2 2.04
Chronic lymphocytic leukemia No 4 2 0.69
Serous ovarian adenocarcinoma No 2 2 0.63
Hepatocarcinoma No 1 1 1.11
Acute myeloid leukemia No 1 1 0.51
Lung squamous cell carcinoma No 1 1 0.57
Stomach adenocarcinoma No 2 1 0.62
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence