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PROX1 has not been detected as a mutational cancer driver

PROX1
Ensembl id ENSG00000117707
Mutated samples
Coding Sequence 99 (1.5%)
Protein Affecting 70 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PROX1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 27 18 4.88
Head and neck squamous cell carcinoma No 13 12 3.20
Breast carcinoma No 6 6 0.52
Stomach adenocarcinoma No 5 5 3.11
Lung adenocarcinoma No 6 4 1.02
Lung squamous cell carcinoma No 6 4 2.30
Renal clear cell carcinoma No 5 4 0.96
Uterine corpus endometrioid carcinoma No 6 3 1.30
Small cell lung carcinoma No 3 3 4.35
Non small cell lung carcinoma No 2 2 6.45
Serous ovarian adenocarcinoma No 3 2 0.63
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 2 1 0.41
Hepatocarcinoma No 5 1 1.11
Bladder carcinoma No 2 1 1.02
Medulloblastoma No 1 1 0.48
Glioblastoma multiforme No 2 1 0.26
Chronic lymphocytic leukemia No 2 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence