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PROS1 has not been detected as a mutational cancer driver

PROS1
Ensembl id ENSG00000184500
Mutated samples
Coding Sequence 83 (1.2%)
Protein Affecting 68 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PROS1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 14 3.79
Lung adenocarcinoma No 11 11 2.81
Head and neck squamous cell carcinoma No 5 5 1.33
Lung squamous cell carcinoma No 5 4 2.30
Renal clear cell carcinoma No 4 4 0.96
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 5 4 2.48
Bladder carcinoma No 3 3 3.06
Breast carcinoma No 3 3 0.26
Small cell lung carcinoma No 3 3 4.35
Prostate adenocarcinoma No 2 2 0.82
Glioblastoma multiforme No 3 2 0.53
Esophageal carcinoma No 4 2 1.37
Hepatocarcinoma No 1 1 1.11
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 2 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Chronic lymphocytic leukemia No 3 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence