IntOGen - POLQ gene cancer mutations

POLQ is detected as a mutational cancer driver

POLQ reports

Methods
Mutation distribution

Gene details

POLQ
Ensembl ID ENSG00000051341 Transcript ID ENST00000264233 Protein ID ENSP00000264233
Cancer types where is driver 6 Cohorts where is driver 7 Mutated samples 71 Mutations 864
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence