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POLN has not been detected as a mutational cancer driver

POLN
Ensembl id ENSG00000130997
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 40 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all POLN gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 11 2.98
Stomach adenocarcinoma No 9 5 3.11
Bladder carcinoma No 7 4 4.08
Breast carcinoma No 7 3 0.26
Lung squamous cell carcinoma No 4 3 1.72
Lung adenocarcinoma No 11 2 0.51
Hepatocarcinoma No 7 2 2.22
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Uterine corpus endometrioid carcinoma No 2 1 0.43
Non small cell lung carcinoma No 3 1 3.23
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Head and neck squamous cell carcinoma No 2 1 0.27
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Pylocytic astrocytoma No 3 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence