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PLXND1 has not been detected as a mutational cancer driver

PLXND1
Ensembl id ENSG00000004399
Mutated samples
Coding Sequence 103 (1.5%)
Protein Affecting 63 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLXND1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 28 14 3.79
Lung adenocarcinoma No 9 9 2.30
Head and neck squamous cell carcinoma No 12 7 1.87
Stomach adenocarcinoma No 6 6 3.73
Breast carcinoma No 5 4 0.35
Lung squamous cell carcinoma No 10 4 2.30
Uterine corpus endometrioid carcinoma No 6 4 1.74
Bladder carcinoma No 6 3 3.06
Renal clear cell carcinoma No 5 3 0.72
Colorectal adenocarcinoma No 4 3 1.31
Prostate adenocarcinoma No 2 1 0.41
Acute myeloid leukemia No 1 1 0.51
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 2 1 1.45
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence