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PIK3R3 mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Breast carcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Head and neck squamous cell carcinoma

PIK3R3
Ensembl id ENSG00000117461
Mutated samples
Coding Sequence 39 (0.6%)
Protein Affecting 21 (0.3%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PIK3R3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 10 3 0.81
Head and neck squamous cell carcinoma Yes 3 3 0.80
Lung adenocarcinoma Yes 2 2 0.51
Breast carcinoma Yes 2 2 0.17
Lung squamous cell carcinoma Yes 2 2 1.15
Uterine corpus endometrioid carcinoma Yes 3 2 0.87
Stomach adenocarcinoma No 3 2 1.24
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Bladder carcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence