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PIK3CB mutations in 8 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Prostate adenocarcinoma, Bladder carcinoma, Breast carcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Neuroblastoma, Stomach adenocarcinoma, Glioblastoma multiforme

PIK3CB
Ensembl id ENSG00000051382
Mutated samples
Coding Sequence 87 (1.3%)
Protein Affecting 71 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PIK3CB gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 32 24 6.50
Breast carcinoma Yes 8 8 0.70
Lung squamous cell carcinoma Yes 4 3 1.72
Stomach adenocarcinoma Yes 3 3 1.86
Glioblastoma multiforme Yes 3 3 0.79
Prostate adenocarcinoma Yes 2 2 0.82
Bladder carcinoma Yes 2 2 2.04
Neuroblastoma Yes 3 2 0.95
Lung adenocarcinoma No 6 6 1.53
Uterine corpus endometrioid carcinoma No 6 6 2.61
Head and neck squamous cell carcinoma No 7 5 1.33
Acute myeloid leukemia No 1 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 2 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence