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PHF6 is detected as a mutational cancer driver in 1 cancer type: Acute myeloid leukemia and in the PAN-cancer analysis

PHF6
Ensembl id ENSG00000156531
Mutated samples
Coding Sequence 47 (0.7%)
Protein Affecting 40 (0.6%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
AML F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PHF6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Acute myeloid leukemia Yes 6 6 3.06
Bladder carcinoma Yes 3 3 3.06
Breast carcinoma Yes 3 3 0.26
Cutaneous melanoma Yes 5 3 0.81
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Lung adenocarcinoma Yes 3 2 0.51
Lung squamous cell carcinoma Yes 2 2 1.15
Renal clear cell carcinoma Yes 2 2 0.48
Stomach adenocarcinoma Yes 2 2 1.24
Acute lymphocytic leukemia No 7 7 5.74
Hepatocarcinoma No 1 1 1.11
Thyroid carcinoma No 1 1 0.31
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Head and neck squamous cell carcinoma No 1 1 0.27
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence