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PHC3 has not been detected as a mutational cancer driver

PHC3
Ensembl id ENSG00000173889
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 40 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PHC3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 13 11 2.98
Lung squamous cell carcinoma No 10 8 4.60
Uterine corpus endometrioid carcinoma No 7 7 3.04
Head and neck squamous cell carcinoma No 8 5 1.33
Breast carcinoma No 8 3 0.26
Lung adenocarcinoma No 1 1 0.26
Chronic lymphocytic leukemia No 1 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 4 1 0.62
Glioblastoma multiforme No 4 1 0.26
Esophageal carcinoma No 3 1 0.68
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Multiple myeloma No 1 0 0.00
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence