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PEAR1 has not been detected as a mutational cancer driver

PEAR1
Ensembl id ENSG00000187800
Mutated samples
Coding Sequence 86 (1.3%)
Protein Affecting 62 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PEAR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 19 5.15
Lung adenocarcinoma No 12 9 2.30
Lung squamous cell carcinoma No 6 5 2.87
Stomach adenocarcinoma No 5 5 3.11
Head and neck squamous cell carcinoma No 6 4 1.07
Breast carcinoma No 4 3 0.26
Serous ovarian adenocarcinoma No 3 3 0.95
Medulloblastoma No 2 2 0.95
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Prostate adenocarcinoma No 2 1 0.41
Acute myeloid leukemia No 1 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 1 1 0.43
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence