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PDE1A has not been detected as a mutational cancer driver

PDE1A
Ensembl id ENSG00000115252
Mutated samples
Coding Sequence 92 (1.4%)
Protein Affecting 69 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PDE1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 42 38 10.30
Lung adenocarcinoma No 7 7 1.79
Breast carcinoma No 3 3 0.26
Head and neck squamous cell carcinoma No 5 3 0.80
Glioblastoma multiforme No 3 3 0.79
Bladder carcinoma No 2 2 2.04
Lung squamous cell carcinoma No 5 2 1.15
Uterine corpus endometrioid carcinoma No 3 2 0.87
Stomach adenocarcinoma No 3 2 1.24
Hepatocarcinoma No 2 1 1.11
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 8 1 0.34
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Neuroblastoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence