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PDE11A has not been detected as a mutational cancer driver

PDE11A
Ensembl id ENSG00000128655
Mutated samples
Coding Sequence 118 (1.7%)
Protein Affecting 77 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PDE11A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 20 5.42
Lung squamous cell carcinoma No 13 11 6.32
Lung adenocarcinoma No 11 8 2.05
Breast carcinoma No 6 6 0.52
Bladder carcinoma No 5 4 4.08
Serous ovarian adenocarcinoma No 4 4 1.27
Head and neck squamous cell carcinoma No 7 4 1.07
Esophageal carcinoma No 6 4 2.74
Renal clear cell carcinoma No 4 3 0.72
Uterine corpus endometrioid carcinoma No 4 3 1.30
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Glioblastoma multiforme No 2 2 0.53
Pancreas adenocarcinoma No 1 1 0.47
Stomach adenocarcinoma No 3 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 9 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence