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PBRM1 is detected as a mutational cancer driver in 1 cancer type: Renal clear cell carcinoma and in the PAN-cancer analysis

PBRM1
Ensembl id ENSG00000163939
Mutated samples
Coding Sequence 256 (3.8%)
Protein Affecting 221 (3.3%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
RCCC FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PBRM1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Renal clear cell carcinoma Yes 140 138 33.09
Head and neck squamous cell carcinoma Yes 12 9 2.40
Lung adenocarcinoma Yes 5 4 1.02
Breast carcinoma Yes 7 4 0.35
Pancreas adenocarcinoma Yes 4 4 1.87
Hepatocarcinoma Yes 4 3 3.33
Neuroblastoma Yes 2 2 0.95
Chronic lymphocytic leukemia Yes 3 2 0.69
Glioblastoma multiforme Yes 2 2 0.53
Cutaneous melanoma No 25 13 3.52
Stomach adenocarcinoma No 12 11 6.83
Bladder carcinoma No 6 6 6.12
Lung squamous cell carcinoma No 8 6 3.45
Uterine corpus endometrioid carcinoma No 8 5 2.17
Lower grade glioma No 6 4 2.37
Esophageal carcinoma No 4 4 2.74
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Small cell lung carcinoma No 2 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Medulloblastoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence