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PASK has not been detected as a mutational cancer driver

PASK
Ensembl id ENSG00000115687
Mutated samples
Coding Sequence 87 (1.3%)
Protein Affecting 60 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PASK gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 12 3.25
Breast carcinoma No 7 6 0.52
Lung adenocarcinoma No 11 5 1.28
Lung squamous cell carcinoma No 5 5 2.87
Uterine corpus endometrioid carcinoma No 7 5 2.17
Stomach adenocarcinoma No 6 5 3.11
Serous ovarian adenocarcinoma No 4 4 1.27
Renal clear cell carcinoma No 4 3 0.72
Head and neck squamous cell carcinoma No 4 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Bladder carcinoma No 2 1 1.02
Neuroblastoma No 2 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 1 1 0.34
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence