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NTRK1 has not been detected as a mutational cancer driver

NTRK1
Ensembl id ENSG00000198400
Mutated samples
Coding Sequence 232 (3.4%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NTRK1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 38 16 4.09
Cutaneous melanoma No 62 16 4.34
Breast carcinoma No 21 6 0.52
Renal clear cell carcinoma No 8 4 0.96
Uterine corpus endometrioid carcinoma No 15 4 1.74
Head and neck squamous cell carcinoma No 8 4 1.07
Prostate adenocarcinoma No 4 3 1.23
Bladder carcinoma No 6 3 3.06
Lung squamous cell carcinoma No 12 3 1.72
Serous ovarian adenocarcinoma No 12 3 0.95
Stomach adenocarcinoma No 10 3 1.86
Small cell lung carcinoma No 5 3 4.35
Colorectal adenocarcinoma No 4 2 0.87
Esophageal carcinoma No 9 2 1.37
Hepatocarcinoma No 2 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Glioblastoma multiforme No 6 1 0.26
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 3 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence