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NRXN1 has not been detected as a mutational cancer driver

NRXN1
Ensembl id ENSG00000179915
Mutated samples
Coding Sequence 297 (4.4%)
Protein Affecting 200 (2.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NRXN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 66 47 12.74
Lung adenocarcinoma No 36 33 8.44
Lung squamous cell carcinoma No 27 20 11.49
Head and neck squamous cell carcinoma No 22 18 4.80
Stomach adenocarcinoma No 17 12 7.45
Uterine corpus endometrioid carcinoma No 12 10 4.35
Colorectal adenocarcinoma No 14 10 4.37
Breast carcinoma No 9 9 0.78
Esophageal carcinoma No 17 8 5.48
Bladder carcinoma No 7 6 6.12
Renal clear cell carcinoma No 6 5 1.20
Serous ovarian adenocarcinoma No 8 5 1.58
Glioblastoma multiforme No 6 5 1.32
Hepatocarcinoma No 7 3 3.33
Prostate adenocarcinoma No 4 2 0.82
Thyroid carcinoma No 3 2 0.62
Small cell lung carcinoma No 2 2 2.90
Acute myeloid leukemia No 1 1 0.51
Chronic lymphocytic leukemia No 21 1 0.34
Multiple myeloma No 2 1 1.45
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 5 0 0.00
Diffuse B cell lymphoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence