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MPL has not been detected as a mutational cancer driver

MPL
Ensembl id ENSG00000117400
Mutated samples
Coding Sequence 40 (0.6%)
Protein Affecting 29 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MPL gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 13 8 2.17
Head and neck squamous cell carcinoma No 4 3 0.80
Glioblastoma multiforme No 3 3 0.79
Lung adenocarcinoma No 3 2 0.51
Uterine corpus endometrioid carcinoma No 3 2 0.87
Small cell lung carcinoma No 2 2 2.90
Bladder carcinoma No 1 1 1.02
Acute myeloid leukemia No 1 1 0.51
Breast carcinoma No 1 1 0.09
Lung squamous cell carcinoma No 2 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Non small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence