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MFN1 has not been detected as a mutational cancer driver

MFN1
Ensembl id ENSG00000171109
Mutated samples
Coding Sequence 50 (0.7%)
Protein Affecting 31 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MFN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 10 7 1.87
Lung adenocarcinoma No 4 3 0.77
Bladder carcinoma No 4 3 3.06
Breast carcinoma No 4 3 0.26
Cutaneous melanoma No 6 3 0.81
Serous ovarian adenocarcinoma No 3 3 0.95
Lung squamous cell carcinoma No 6 2 1.15
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Chronic lymphocytic leukemia No 3 1 0.34
Stomach adenocarcinoma No 1 1 0.62
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Hepatocarcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence