Top
MED12L has not been detected as a mutational cancer driver

MED12L
Ensembl id ENSG00000144893
Mutated samples
Coding Sequence 348 (5.1%)
Protein Affecting 146 (2.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MED12L gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 93 43 11.65
Lung adenocarcinoma No 29 16 4.09
Head and neck squamous cell carcinoma No 31 15 4.00
Lung squamous cell carcinoma No 26 12 6.90
Stomach adenocarcinoma No 24 11 6.83
Renal clear cell carcinoma No 15 9 2.16
Breast carcinoma No 22 7 0.61
Uterine corpus endometrioid carcinoma No 18 6 2.61
Esophageal carcinoma No 13 5 3.42
Serous ovarian adenocarcinoma No 10 4 1.27
Bladder carcinoma No 8 3 3.06
Small cell lung carcinoma No 4 3 4.35
Colorectal adenocarcinoma No 16 3 1.31
Hepatocarcinoma No 3 2 2.22
Prostate adenocarcinoma No 5 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 3 1 0.48
Non small cell lung carcinoma No 3 1 3.23
Chronic lymphocytic leukemia No 9 1 0.34
Multiple myeloma No 4 1 1.45
Glioblastoma multiforme No 2 1 0.26
Thyroid carcinoma No 4 0 0.00
Lower grade glioma No 3 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence