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MAML3 has not been detected as a mutational cancer driver

MAML3
Ensembl id ENSG00000196782
Mutated samples
Coding Sequence 73 (1.1%)
Protein Affecting 43 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAML3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 7 1.90
Breast carcinoma No 6 5 0.44
Renal clear cell carcinoma No 5 5 1.20
Lung adenocarcinoma No 6 4 1.02
Head and neck squamous cell carcinoma No 7 4 1.07
Bladder carcinoma No 4 3 3.06
Uterine corpus endometrioid carcinoma No 8 3 1.30
Lower grade glioma No 3 3 1.78
Stomach adenocarcinoma No 3 3 1.86
Esophageal carcinoma No 3 2 1.37
Prostate adenocarcinoma No 2 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence