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LRRC8B has not been detected as a mutational cancer driver

LRRC8B
Ensembl id ENSG00000197147
Mutated samples
Coding Sequence 41 (0.6%)
Protein Affecting 28 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRRC8B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 9 4 1.08
Uterine corpus endometrioid carcinoma No 4 3 1.30
Prostate adenocarcinoma No 2 2 0.82
Breast carcinoma No 2 2 0.17
Lung squamous cell carcinoma No 2 2 1.15
Stomach adenocarcinoma No 2 2 1.24
Head and neck squamous cell carcinoma No 3 2 0.53
Glioblastoma multiforme No 2 2 0.53
Lung adenocarcinoma No 1 1 0.26
Bladder carcinoma No 1 1 1.02
Medulloblastoma No 1 1 0.48
Renal clear cell carcinoma No 4 1 0.24
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence