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LRPPRC is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma

LRPPRC
Ensembl id ENSG00000138095
Mutated samples
Coding Sequence 64 (0.9%)
Protein Affecting 51 (0.8%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
CM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRPPRC gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 19 17 4.61
Head and neck squamous cell carcinoma No 7 7 1.87
Lung adenocarcinoma No 6 5 1.28
Renal clear cell carcinoma No 5 4 0.96
Breast carcinoma No 6 3 0.26
Lung squamous cell carcinoma No 3 3 1.72
Stomach adenocarcinoma No 4 3 1.86
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 2 1 0.41
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 1 1 0.43
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 2 1 0.32
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Chronic lymphocytic leukemia No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence