IntOGen - LRP1B gene cancer mutations

LRP1B is detected as a mutational cancer driver

LRP1B reports

Methods
Mutation distribution

Gene details

LRP1B
Ensembl ID ENSG00000168702 Transcript ID ENST00000389484 Protein ID ENSP00000374135
Cancer types where is driver 32 Cohorts where is driver 69 Mutated samples 1,109 Mutations 4,911
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence