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LRP1B has not been detected as a mutational cancer driver

LRP1B
Ensembl id ENSG00000168702
Mutated samples
Coding Sequence 779 (11.5%)
Protein Affecting 626 (9.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRP1B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 164 138 37.40
Lung adenocarcinoma No 115 102 26.09
Head and neck squamous cell carcinoma No 83 71 18.93
Lung squamous cell carcinoma No 71 65 37.36
Stomach adenocarcinoma No 50 39 24.22
Esophageal carcinoma No 40 33 22.60
Small cell lung carcinoma No 29 25 36.23
Colorectal adenocarcinoma No 28 23 10.04
Breast carcinoma No 22 15 1.31
Uterine corpus endometrioid carcinoma No 17 15 6.52
Bladder carcinoma No 16 13 13.27
Serous ovarian adenocarcinoma No 13 13 4.11
Renal clear cell carcinoma No 15 12 2.88
Prostate adenocarcinoma No 11 9 3.70
Glioblastoma multiforme No 9 8 2.11
Hepatocarcinoma No 13 7 7.78
Neuroblastoma No 7 7 3.33
Pancreas adenocarcinoma No 8 6 2.80
Chronic lymphocytic leukemia No 29 6 2.07
Non small cell lung carcinoma No 8 5 16.13
Multiple myeloma No 6 5 7.25
Lower grade glioma No 6 4 2.37
Medulloblastoma No 4 2 0.95
Thyroid carcinoma No 3 2 0.62
Acute myeloid leukemia No 3 1 0.51
Pylocytic astrocytoma No 9 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence