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LCT has not been detected as a mutational cancer driver

LCT
Ensembl id ENSG00000115850
Mutated samples
Coding Sequence 232 (3.4%)
Protein Affecting 160 (2.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LCT gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 61 36 9.76
Lung adenocarcinoma No 31 25 6.39
Lung squamous cell carcinoma No 23 19 10.92
Breast carcinoma No 15 11 0.96
Head and neck squamous cell carcinoma No 14 10 2.67
Esophageal carcinoma No 9 8 5.48
Uterine corpus endometrioid carcinoma No 12 7 3.04
Small cell lung carcinoma No 8 7 10.14
Serous ovarian adenocarcinoma No 6 6 1.90
Stomach adenocarcinoma No 10 6 3.73
Bladder carcinoma No 4 4 4.08
Glioblastoma multiforme No 7 4 1.06
Colorectal adenocarcinoma No 6 3 1.31
Prostate adenocarcinoma No 4 2 0.82
Renal clear cell carcinoma No 3 2 0.48
Non small cell lung carcinoma No 3 2 6.45
Acute lymphocytic leukemia No 2 2 1.64
Hepatocarcinoma No 2 1 1.11
Pancreas adenocarcinoma No 2 1 0.47
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 3 1 0.34
Lower grade glioma No 2 1 0.59
Medulloblastoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence