IntOGen - KMT2A gene cancer mutations

KMT2A is detected as a mutational cancer driver

KMT2A reports

Methods
Mutation distribution

Gene details

KMT2A
Ensembl ID ENSG00000118058 Transcript ID ENST00000534358 Protein ID ENSP00000436786
Cancer types where is driver 9 Cohorts where is driver 14 Mutated samples 113 Mutations 1,219
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence