IntOGen - KLF5 gene cancer mutations

KLF5 is detected as a mutational cancer driver

KLF5 reports

Methods
Mutation distribution

Gene details

KLF5
Ensembl ID ENSG00000102554 Transcript ID ENST00000377687 Protein ID ENSP00000366915
Cancer types where is driver 3 Cohorts where is driver 3 Mutated samples 38 Mutations 235
Mode of action Ambiguous
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence