IntOGen - GRM3 gene cancer mutations

GRM3 is detected as a mutational cancer driver

GRM3 reports

Methods
Mutation distribution

Gene details

GRM3
Ensembl ID ENSG00000198822 Transcript ID ENST00000361669 Protein ID ENSP00000355316
Cancer types where is driver 3 Cohorts where is driver 4 Mutated samples 50 Mutations 910
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence