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GRHL3 has not been detected as a mutational cancer driver

GRHL3
Ensembl id ENSG00000158055
Mutated samples
Coding Sequence 45 (0.7%)
Protein Affecting 31 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GRHL3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 10 6 1.63
Bladder carcinoma No 4 4 4.08
Breast carcinoma No 6 4 0.35
Head and neck squamous cell carcinoma No 4 4 1.07
Glioblastoma multiforme No 4 4 1.06
Lung squamous cell carcinoma No 2 2 1.15
Stomach adenocarcinoma No 5 2 1.24
Prostate adenocarcinoma No 1 1 0.41
Lung adenocarcinoma No 1 1 0.26
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 2 1 0.68
Renal clear cell carcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence