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FUBP1 is detected as a mutational cancer driver in 2 cancer types: Lower grade glioma, Head and neck squamous cell carcinoma and in the PAN-cancer analysis

FUBP1
Ensembl id ENSG00000162613
Mutated samples
Coding Sequence 70 (1.0%)
Protein Affecting 53 (0.8%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
LGG FR
HNSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FUBP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lower grade glioma Yes 18 18 10.65
Cutaneous melanoma Yes 9 6 1.63
Head and neck squamous cell carcinoma Yes 8 6 1.60
Stomach adenocarcinoma Yes 5 5 3.11
Lung squamous cell carcinoma Yes 4 4 2.30
Lung adenocarcinoma Yes 4 3 0.77
Uterine corpus endometrioid carcinoma Yes 7 3 1.30
Breast carcinoma Yes 3 2 0.17
Bladder carcinoma No 2 2 2.04
Medulloblastoma No 2 1 0.48
Renal clear cell carcinoma No 1 1 0.24
Small cell lung carcinoma No 2 1 1.45
Glioblastoma multiforme No 1 1 0.26
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence