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FBXW7 is detected as a mutational cancer driver in 8 cancer types: Bladder carcinoma, Medulloblastoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Chronic lymphocytic leukemia, Colorectal adenocarcinoma plus in 2 more and in the PAN-cancer analysis

FBXW7
Ensembl id ENSG00000109670
Mutated samples
Coding Sequence 156 (2.3%)
Protein Affecting 143 (2.1%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
BLCA F
MB F
CM F
UCEC CFR
CLL F
COREAD CFR
HNSC FR
ALL F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FBXW7 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 27 27 11.74
Colorectal adenocarcinoma Yes 27 25 10.92
Head and neck squamous cell carcinoma Yes 20 18 4.80
Cutaneous melanoma Yes 12 12 3.25
Breast carcinoma Yes 10 10 0.87
Bladder carcinoma Yes 9 9 9.18
Lung adenocarcinoma Yes 6 5 1.28
Acute lymphocytic leukemia Yes 4 4 3.28
Medulloblastoma Yes 3 3 1.43
Chronic lymphocytic leukemia Yes 5 3 1.03
Serous ovarian adenocarcinoma Yes 3 3 0.95
Esophageal carcinoma Yes 3 2 1.37
Lung squamous cell carcinoma No 12 9 5.17
Stomach adenocarcinoma No 8 7 4.35
Glioblastoma multiforme No 2 2 0.53
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Thyroid carcinoma No 1 1 0.31
Small cell lung carcinoma No 1 1 1.45
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence