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FAT4 has not been detected as a mutational cancer driver

FAT4
Ensembl id ENSG00000196159
Mutated samples
Coding Sequence 487 (7.2%)
Protein Affecting 386 (5.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FAT4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 133 105 28.46
Lung adenocarcinoma No 53 41 10.49
Stomach adenocarcinoma No 42 37 22.98
Head and neck squamous cell carcinoma No 40 30 8.00
Uterine corpus endometrioid carcinoma No 30 24 10.43
Lung squamous cell carcinoma No 30 23 13.22
Colorectal adenocarcinoma No 25 21 9.17
Esophageal carcinoma No 23 20 13.70
Breast carcinoma No 20 17 1.48
Bladder carcinoma No 12 11 11.22
Small cell lung carcinoma No 10 10 14.49
Renal clear cell carcinoma No 9 7 1.68
Prostate adenocarcinoma No 7 5 2.06
Non small cell lung carcinoma No 6 5 16.13
Multiple myeloma No 7 5 7.25
Chronic lymphocytic leukemia No 10 4 1.38
Lower grade glioma No 5 4 2.37
Glioblastoma multiforme No 5 4 1.06
Hepatocarcinoma No 4 3 3.33
Serous ovarian adenocarcinoma No 6 3 0.95
Pancreas adenocarcinoma No 2 2 0.93
Acute lymphocytic leukemia No 3 2 1.64
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Diffuse B cell lymphoma No 1 1 4.35
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence