IntOGen - FAT4 gene cancer mutations

FAT4 is detected as a mutational cancer driver

FAT4 reports

Methods
Mutation distribution

Gene details

FAT4
Ensembl ID ENSG00000196159 Transcript ID ENST00000674496 Protein ID ENSP00000501473
Cancer types where is driver 26 Cohorts where is driver 41 Mutated samples 523 Mutations 3,234
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence