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DNMT3A is detected as a mutational cancer driver in 2 cancer types: Lung adenocarcinoma, Acute myeloid leukemia and in the PAN-cancer analysis

DNMT3A
Ensembl id ENSG00000119772
Mutated samples
Coding Sequence 134 (2.0%)
Protein Affecting 115 (1.7%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
LUAD F
AML CFR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DNMT3A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Acute myeloid leukemia Yes 51 51 26.02
Lung adenocarcinoma Yes 9 9 2.30
Cutaneous melanoma Yes 12 7 1.90
Head and neck squamous cell carcinoma Yes 12 7 1.87
Stomach adenocarcinoma Yes 4 4 2.48
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Serous ovarian adenocarcinoma Yes 3 3 0.95
Colorectal adenocarcinoma Yes 2 2 0.87
Lung squamous cell carcinoma No 10 7 4.02
Breast carcinoma No 5 5 0.44
Renal clear cell carcinoma No 5 5 1.20
Thyroid carcinoma No 5 5 1.55
Esophageal carcinoma No 3 2 1.37
Prostate adenocarcinoma No 3 1 0.41
Hepatocarcinoma No 2 1 1.11
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 2 1 0.34
Small cell lung carcinoma No 1 1 1.45
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence