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DLG1 mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Bladder carcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma, Esophageal carcinoma

DLG1
Ensembl id ENSG00000075711
Mutated samples
Coding Sequence 60 (0.9%)
Protein Affecting 46 (0.7%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DLG1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 15 10 2.71
Stomach adenocarcinoma Yes 6 5 3.11
Lung squamous cell carcinoma Yes 5 4 2.30
Bladder carcinoma Yes 3 3 3.06
Serous ovarian adenocarcinoma Yes 3 3 0.95
Esophageal carcinoma Yes 3 3 2.05
Breast carcinoma No 8 7 0.61
Head and neck squamous cell carcinoma No 5 5 1.33
Lung adenocarcinoma No 1 1 0.26
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Lower grade glioma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence