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DLEC1 has not been detected as a mutational cancer driver

DLEC1
Ensembl id ENSG00000008226
Mutated samples
Coding Sequence 124 (1.8%)
Protein Affecting 77 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DLEC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 49 31 8.40
Lung adenocarcinoma No 9 6 1.53
Uterine corpus endometrioid carcinoma No 6 5 2.17
Head and neck squamous cell carcinoma No 7 5 1.33
Bladder carcinoma No 4 4 4.08
Breast carcinoma No 5 4 0.35
Renal clear cell carcinoma No 6 3 0.72
Stomach adenocarcinoma No 5 3 1.86
Lung squamous cell carcinoma No 4 2 1.15
Pancreas adenocarcinoma No 2 2 0.93
Thyroid carcinoma No 2 2 0.62
Small cell lung carcinoma No 2 2 2.90
Glioblastoma multiforme No 5 2 0.53
Esophageal carcinoma No 4 2 1.37
Medulloblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Prostate adenocarcinoma No 3 0 0.00
Hepatocarcinoma No 2 0 0.00
Neuroblastoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence