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DENND4B has not been detected as a mutational cancer driver

DENND4B
Ensembl id ENSG00000198837
Mutated samples
Coding Sequence 105 (1.5%)
Protein Affecting 51 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DENND4B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 13 3.52
Esophageal carcinoma No 7 6 4.11
Uterine corpus endometrioid carcinoma No 11 5 2.17
Head and neck squamous cell carcinoma No 7 5 1.33
Bladder carcinoma No 11 3 3.06
Breast carcinoma No 11 3 0.26
Lung squamous cell carcinoma No 4 3 1.72
Lung adenocarcinoma No 9 2 0.51
Multiple myeloma No 2 2 2.90
Serous ovarian adenocarcinoma No 4 2 0.63
Stomach adenocarcinoma No 4 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Renal clear cell carcinoma No 2 1 0.24
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Prostate adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Glioblastoma multiforme No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence